Fresh analysis reveals that individuals who come off blockbuster slimming jabs like Mounjaro or Wegovy tend to recover shed pounds at a significantly accelerated pace than those who end conventional lifestyle regimens.
Research printed in a major medical journal shows that while overweight people can lose a large proportion of their body weight while on the medication, the mass comes back at an average rate of nearly a kilo each month upon discontinuation.
"Users using these medications must be aware of the potential of fast rebound weight gain when the therapy concludes," warns lead investigator Dr. Susan Jebb.
Such speed of recovery implies a reversion to original weight within about 18 months.
Comparing Approaches
The analysis, which looked at 37 of trials involving over 9,000 of patients, compared the results of these new drugs with other pills.
Scientists note that individuals who shed pounds through diet and exercise generally see a more gradual creep back—around 100 grams monthly—after stopping.
Understanding the Fast Rebound
Experts propose the way of the injections explains the amplified rebound.
The injections copy a body's own chemical called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Artificially providing the hormone concentrations far above than normal may cause the body to produce less of its endogenous GLP-1, and may also reduce sensitivity to its effects," said Dr. Adam Collins, a nutrition specialist.
"Stopping of this hormone supplement means hunger is uncontrolled, making binge eating a significant risk."
An Ongoing Issue?
The NHS advise the injections for people with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
Professionals say that, due to the likelihood of relapse, the therapy should be considered life-long.
This view is supported by drug manufacturers, who say that the findings "underscore the chronic nature of excess weight," comparing it to managing conditions like high blood pressure.
User Experiences
Users who have stopped the jabs report a sudden return of cravings.
"It felt as if a switch that goes on and I was suddenly starving," recalled one woman.
This challenge is exacerbated if patients have not established lasting dietary or behavioural modifications during therapy.
Widespread Interest
Figures show that a significant number of people in the UK have used weight-loss jabs in the past year, with desire continuing to grow.
- Adoption is higher among females than men.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion obtain the medications through private healthcare rather than public health services.
In conclusion, researchers caution that while the jabs are effective tools for weight loss, they are not a permanent cure and maintained weight loss likely depends on ongoing lifestyle support.
